Program evaluation can be used to assess health and education programs, health promotion programs, and social programs among others. Program evaluation can provide valuable insight into program goals, activities and target population, program strengths, areas for program improvement, and the cost-effectiveness of a program. It is an important accountability tool and can be used to justify continued funding for programs or new directions in programming. To obtain maximum benefit from program evaluations and research with Aboriginal peoples and organizations, they must be considered full partners in the project. Many Indigenous scholars have articulated respectful approaches for engaging in such evaluations. This paper will briefly review different types of program evaluation activities and discuss Indigenous approaches and ethical guidelines for engaging in a program evaluation.